NEWS FROM THE EROGLU LAB
Explore Cutting-Edge Imaging at SABITA Satellite Meeting!
Join us for a day of discovery at the SABITA Satellite Symposium, aligned with the annual redox meeting of the Society for Free Radical Research Europe (SFFR-E) at 8th of June 2024. Themed “Seeing is Believing,” this event offers early career researchers an exclusive opportunity.
Limited to 50 participants, the morning session features world-leading speakers, open to 150 attendees upon registration. The afternoon transforms into a hands-on experience at our Zeiss labs@location center, with five parallel sessions for selected attendees chosen by trainers.
Don’t miss this chance to dive into the latest imaging technologies and gain insights from experts. Explore more at Redox Istanbul 2024.
08 June 2024
Captivate Your Vision: BIOIMAGE 2024 Workshops Unleash Innovation at SABITA!
Prepare to embark on an exhilarating journey into the fascinating world of bioimaging as we proudly announce the upcoming BIOIMAGE 2024 workshops. Set to take place on the 8th of June, within the satellite symposium under the prestigious Redox Istanbul 2024 event, hosted right here at our esteemed institute, SABITA.
Get ready to immerse yourself in a day filled with enlightening talks, interactive sessions, and hands-on workshops, carefully curated to ignite your curiosity and unleash your potential in the realm of bioimaging. Whether you’re a seasoned expert, an aspiring researcher, or simply passionate about exploring the frontiers of science, this event promises an unparalleled opportunity to delve into the latest advancements and techniques shaping the future of imaging technologies.
Discover the power of cutting-edge imaging tools, learn from renowned experts in the field, and network with fellow enthusiasts and professionals eager to push the boundaries of scientific exploration. From exploring novel imaging modalities to gaining insights into advanced image analysis techniques, BIOIMAGE 2024 workshops offer a dynamic platform for collaboration, innovation, and discovery.
Mark your calendars, spread the word, and join us for an unforgettable experience at BIOIMAGE 2024 workshops. Together, let’s embark on a transformative journey towards unlocking new insights, pushing boundaries, and shaping the future of bioimaging. We look forward to welcoming you and celebrating the spirit of innovation and exploration at SABITA!
30 April 2024
Beykoz Seaside Soiree: Eroglu Lab’s Spring Social Gathering!
Eroglu Lab recently enjoyed a delightful spring social activity at Beykoz seaside, with the picturesque backdrop of the Silos Museum. It was a perfect opportunity for our team to unwind, connect, and enjoy the refreshing seaside ambiance. With laughter, camaraderie, and beautiful views, it was an afternoon to remember for all lab members. Here’s to many more memorable moments together!
27 March 2024
Unraveling the Mysteries of the Blood-Brain Barrier!
We had the privilege of hosting Nur Mustafaoğlu from Sabancı University, who delivered a captivating talk shedding light on her research concerning the blood-brain barrier. Her insightful presentation sparked engaging discussions, offering valuable insights into this complex area of study. This event not only fostered collaboration but also paved the way for future connections, opening new doors for innovative research endeavors.
25 March 2024
Eroglu Lab’s Paper Featured on ACS Sensors Cover!
We’re thrilled to announce that our latest paper has been chosen as the cover feature for ACS Sensors! A round of applause to our dedicated team members whose hard work made this achievement possible: Asal Zaki, Mehmet Şerif Aydın, Esra Nur Yiğit, Emre Vatandaslar, and Gürkan Öztürk.
What is the cover showing:
The cover art showcases the intricate dance of signals emanating from a wounded neuron, captured through laser-induced injury. Delve into the secrets of cellular communication as light triggers a symphony of molecular responses. It’s a visual representation of the groundbreaking research encapsulated within our paper.
19 March 2024
Insights from Prof. Dr. Devrim Gozuacik! During his recent seminar at Medipol SABITA, Prof. Dr. Devrim Gozuacik captivated our attention with his group’s innovative strategies for translating bench research into practical solutions for cancer patients. Prof. Dr. Gozuacik’s commitment to bridging the gap between research and application is truly inspiring. His team’s work at Koç University promises transformative outcomes, offering hope for those affected by cancer.
At SABITA, we are energized by the opportunity to contribute to this translational journey, utilizing science to create tangible impacts in patient care. We extend heartfelt gratitude to Prof. Dr. Gozuacik for sharing his insights and igniting our passion for this critical aspect of scientific inquiry.
15 March 2024
Lab Iftar: Embracing Unity and Joy!
In the spirit of Ramadan, our lab shared a heartfelt iftar, each member contributing to a table filled with joy and gratitude. Amidst laughter and engaging conversations, we cherished the simple pleasures of togetherness. Wishing everyone a Ramadan Kareem, may this blessed month be filled with unity and reflection!
5 – 8 March 2024
Enriching Experiences at King’s College London Training School
Dr. Emrah Eroğlu enjoyed an enlightening experience at the Physiological Oxygen and NRF2 Redox Signaling Training School, hosted by King’s College London. Gratitude to the organizers. Discussions among experts and early career researchers, with insightful seminars by the field most common fıgures. Their contributions were invaluable to our understanding of the latest advancements in our field.
01 March 2024
ACBI Workshop Unites Asian and Turkish Scientists!
The Asian Chemical Biology Initiative (ACBI) recently convened in Istanbul, uniting 25 esteemed professors under the coordination of Motonari Uesugi, Takeaki Ozawa, and Mitsue Nakashima. Over three dynamic days, we engaged in workshops fostering connections with Turkish scientists and students.
In addition, Medipol SABITA hosted a captivating mini-symposium, graced by three distinguished professors. This collaboration strengthened ties and fostered innovation in chemical biology. Heartfelt thanks to professors Surajit Ghosh, Jun-Seok Lee, Hiroshi Abe, and Young Tae Chang for their invaluable contributions.
26 February 2024
Eroğlu Lab Welcomes Assist. Prof. Ahmed Abdelfattah from Brown University
Eroğlu Lab hosted Assist. Prof. Ahmed Abdelfattah from Brown University, who delivered an enlightening talk on his research titled “Genetically Encoded Voltage Indicators for Optical Monitoring of Neural Activity.”
We would like to express our sincere gratitude to Dr. Abdelfattah for sharing his expertise and contributing to the vibrant scientific atmosphere at SABITA. This collaborative endeavor holds the promise of exciting discoveries and advancements in our respective fields. Stay tuned for updates on this thrilling collaboration!
24 February 2024
Eroğlu Lab Hosts Inspiring Talk by Assoc. Prof. Umut Şahin on SUMOylation!
We had the honor of hosting Assoc. Prof. Umut Şahin from Boğaziçi University. His captivating talk, titled “SUMOylation in Health and Disease and Its Potential for Targeted Therapies,” provided valuable insights into the intricate world of SUMOylation.
During the visit, Assoc. Prof. Şahin was introduced to our team and research endeavors. Engaging scientific discussions unfolded. This meeting served as a catalyst, opening the door for a new and valuable collaboration between SABITA and Assoc. Prof. Şahin. Keep an eye on the promising outcomes that arise from this enriching exchange of ideas and expertise!
15 February 2024
Sleep’s Secrets with Prof. Halil Kavakli! We were honored to host Prof. Dr. Halil Kavakli for an enlightening seminar on the intricate molecular mechanisms governing our circadian rhythm at Medipol SABITA. His insights into the nexus between sleep patterns and their impact on health were eye-opening.
Understanding our body’s internal clock is crucial, and Prof. Kavaklı’s expertise shed light on the forefront of this field. His visit sparked exciting discussions and potential collaborations, opening doors to innovative research endeavors at the intersection of chronobiology and our collective expertise. Thank you, Prof. Kavakli, for sharing your knowledge. Looking forward to nurturing collaborations and driving impactful discoveries together!
5 February 2024
A Journey Through Cell Cycle Dynamics with Dr. Ayse Koca Caydasi! It was an honor to host Dr. Ayse Koca Caydasi, a distinguished expert in Molecular Biology and Genetics from Koç University, at our Institute Medipol SABITA for a captivating seminar.
Dr. Caydas shared her profound knowledge and insights, focusing on the spatial and temporal coordination of cell cycle events, particularly in asymmetric cell division using Saccharomyces cerevisiae (baker’s yeast). Her groundbreaking contributions to understanding aging, coupled with ongoing research in novel cell cycle regulatory mechanisms, are pivotal in the fight against cancer.
We express our sincere gratitude to Dr. Caydas for generously sharing her expertise, contributing to our expanding knowledge base at Medipol SABITA.
2 February 2024
Spreading Joy at Eroglu Lab: Heartwarming Gift Exchange Event!
Embracing the beautiful concept of sharing love through gifts, inspired by the Hadith, we organized a heartwarming gift exchange at Eroğlu Lab. Each member drew a name and delighted their chosen colleague with a thoughtful surprise. The entire experience was nothing short of amazing, from the joy of selecting meaningful gifts to the delightful element of surprise. This unique and memorable activity truly enhanced the spirit of our lab, fostering camaraderie and joy among the team.
31 January 2024
New Paper: Genetically Encoded Biosensors Unveil Neuronal Injury Dynamics via Multichromatic ATP and Calcium Imaging.
Eroğlu Lab proudly announces the publication of a groundbreaking paper titled “Genetically Encoded Biosensors Unveil Neuronal Injury Dynamics via Multichromatic ATP and Calcium Imaging” in the prestigious ACS journal. This research marks a significant role in understanding neuronal injury dynamics through advanced multichromatic ATP and calcium imaging techniques. Stay tuned for more insights into the cutting-edge research from Eroğlu Lab. Congratulations to all involved! Read paper here.
24 January 2024
Dr. Sukru Anil Dogan, PhD, Graces Medipol SABITA with His Expertise! We recently had the privilege of hosting the distinguished Dr. Sukru Anil Dogan, PhD, from Boğaziçi University at our esteemed institute, Medipol SABITA. Anıl, a respected expert in the field, presented a memorable and intellectually stimulating session, delving into the intricacies of mitochondrial oxidative stress and its correlation with aging.
The engaging discussions that followed enriched our understanding and sparked new perspectives on this vital aspect of scientific inquiry. Such collaborative exchanges are integral to the growth of knowledge and innovation within our scientific community. A big thank you to Dr. Sukru Anil Dogan! We eagerly anticipate his next visit for more insightful conversations and collaborations at Medipol SABITA.
29 December 2023
Eroğlu Lab Wraps Up 2023 with Journal Club at Sağlık Bilimleri Üniversitesi Validebağ Araştırma Parkı!
On the final day of 2023, we concluded our weekly journal club series at Sağlık Bilimleri Üniversitesi Validebağ Araştırma Parkı. Our Ph.D. student, Melike Seçilmiş, presented a novel biosensor technology, sparking enjoyable discussions with esteemed colleagues Ahmet Katı, Sevde Altuntas, and team members.
These regular gatherings with friends who share our passion for collaboration and pushing the boundaries of scientific discovery are a way to encourage teamwork. Grateful for the hospitality, we extend our thanks to mentors and students alike. Looking forward to continued collaboration and impactful contributions to our country in 2024!
25 December 2023
A Trip to Our Inspiring Past! In December, Eroğlu Lab embarked on a fascinating visit to the Istanbul Museum of the History of Science and Technology in Islam. Conceptualized by Prof. Dr. Fuat Sezgin, an Islamic science historian, the museum showcases work, devices, and tools invented and developed by Islamic scientists between the 9th and 16th centuries.
Our main aim was to draw inspiration from our rich past and apply it to our present lives. Our ancestors were pioneers in various sciences, and many of the innovations they developed centuries are our main tools today. Spending the day observing their remarkable achievements was nothing short of amazing, reminding us of the enduring legacy of scientific discovery in Islamic history.
21 December 2023
Eroğlu Lab’s Inspirational Visit to Koç University! We had enjoyed an inspiring visit to Koç University, marking our second visit this year. It’s always a privilege to be in the presence of brilliance, and Koç University truly stands as one of Türkiye’s most prestigious institutions. During our visit, meeting with Elif Nur Firat-Karalar, Ayse Koca Caydasi, and Halil Kavakli proved incredibly insightful. The exchange of iideas and knowledge among experts within the Turkish scientific community is crucial for scientific progress. Dr. Emrah Eroğlu had the honor of presenting a seminar on biosensor technologies and chemogenetic approaches, exploring cutting-edge advancements in our field. The enthusiasm and engagement from the Koç University community were truly energizing, further strengthening the ties between our institutions.
14 -16 December 2023
Dr. Emrah Eroğlu Explores Cutting-Edge Research at EPFL, Switzerland!
Dr. Emrah Eroğlu had the privilege of visiting Hilal Lashuel’s cutting-edge lab at EPFL, Switzerland, where he shared our latest advancements in biosensors and chemogenetics. Engaging in meaningful discussions with the research team and faculty paved the way for future collaborations.
During the visit, a connection was established with the brilliant Emanuele Buratti, laying the foundation for an exciting partnership. Anticipation is high as we prepare to reciprocate the collaboration by hosting Emanuele at our institute, Medipol SABITA, in Istanbul.
29 November – 2 December 2023
Eroğlu Lab Shines at the 9th International Drug Design Congress in Istanbul! The vibrant research landscape in Türkiye continues to impress, exemplified by our participation in the 9th International Drug Design Congress hosted by Bahcesehir University in Istanbul. Thanks to the organizer, Prof. Dr. Serdar Durdağı, for orchestrating this remarkable event!
As an invited speaker, Dr. Emrah Eroğlu had the honor of presenting cutting-edge research on drug testing, sharing insights, and contributing to vibrant discussions in the field. Additionally, he chaired a session, facilitating knowledge exchange among brilliant minds in drug design.
A special shoutout to our talented PhD student Asal Zaki, whose exceptional presentation skills earned her the recognition of the best presentation award! We eagerly anticipate continued collaboration and exploration in this dynamic field.
23 November 2023
Blending History and Camaraderie in Küçüksu Kasrı!
In November, we embarked on a captivating historical visit to Küçüksu Kasrı for our monthly social activity. The day commenced with a delightful Turkish breakfast against the breathtaking view of the Bosphorus, setting the stage for meaningful discussions on self-improvement and enhancing our lab’s development.
Following our engaging breakfast, we explored Küçüksu Kasrı, immersing ourselves in the rich history of the Ottoman Empire. The visit allowed us to witness the places where the Ottomans once ruled the world. A perfect blend of social and historical experiences, the day served as a reminder of our inspiring history and rejuvenated our energy for fostering a better lab environment.
23 October 2023
Eroglu Lab’s Inspiring Weekly Meeting at Nevmekan Kandilli!
Eroğlu Lab gathered for their weekly meeting at Nevmekan Kandilli, a historical place in Üsküdar.
In this unique setting, we shared our latest scientific findings, engaging in fruitful discussions on ways to enhance our lab and personal development.
We firmly believe that such gatherings are crucial for fostering collaboration, creativity, and camaraderie within our team. These activities play a pivotal role in nurturing a conducive environment for groundbreaking research and continuous improvement.
17 October 2023
Şeyma Kablan Çimen Shines as an Emerging Leader in Redox Biology!
We are thrilled to announce that Şeyma Kablan Çimen, our exceptional PhD student, has been chosen to participate in the ‘Emerging Leaders in Redox Biology’ mini symposium!
Şeyma will showcase her latest research findings, leveraging our cutting-edge chemogenetic technologies. Her work unveils a deeper understanding of the intricate interplay between energy metabolism and redox imbalance. Save the date: 17.Oct., 15:00 CET. Visit SFRR-E page for more details.
A big Thank You to SFRR-Efor this incredible opportunity, and we are looking forward to hearing about all the innovative research at the symposium from the other talents.
12 October 2023
Reconnecting with Roots Through a Visit to Medical University of Graz!
Dr. Emrah Eroğlu took a journey into the past by visiting his former PI, Prof. Roland Malli, who is also one of our esteemed collaborators at the Medical University of Graz. During this visit, Dr. Eroğlu had the chance of meeting our alumni lab member, Yusuf Ceyhun Erdoğan, who is now pursuing a Ph.D. under Roland’s mentorship.
Such reunions are nothing short of inspiring, as they embody the enduring bonds formed within our scientific community. The exchange of ideas and experiences during these meetings enriches our collective journey and fosters a spirit of continuous growth and collaboration.
11-12 October 2023
Dr. Emrah Eroğlu’s Academic Journey: Vienna and Graz! Dr. Emrah Eroğlu embarked on an enriching academic journey, starting at Vienna Medical University. Thanks to Stefan Grünert from biolution GmbH for arranging this fantastic collaboration meeting. During his visit, Dr. Eroğlu joined Dr. Theresa Balber in exciting experiments, initiating a promising collaboration in vascular biology.
The journey continued to Graz for the annual Nrf2 Meeting, organized by Brigitte Winkelhofer-Roob and Christina Morgenstern, Ph.D. Special thanks to Antonio Cuadrado, president of Cost-Action BenBedPhar, for making this gathering possible. The highlight was hearing from legendary Prof. Dr. Masayuki Yamamoto, a pioneer in the field. Dr. Eroğlu shared groundbreaking findings on hydrogen peroxide and oxygen’s role in Nrf2 regulation in collaboration with Giovanni E. Mann from King’s College London, sparking inspiring discussions about the future of their research.
Grateful for the connections made, knowledge shared, and the promise of new horizons in our research.
14 September 2023
Eroglu Lab Extends a Warm Welcome to Dr. Elif Nur Firat-Karalar at Medipol SABITA! We had the honor of hosting Dr. Elif Nur Firat-Karalar from Koç University at our institute. Dr. Karalar, a distinguished researcher in cilia and cytoskeleton, delivered an insightful seminar that left our team inspired. With two ERC grants and the prestigious EMBO grant, Dr. Karalar’s contributions to the scientific community are truly exceptional, reflecting the high standards of research in Türkiye. Special thanks to Dr. Karalar for sharing her expertise and inspiring our team with her groundbreaking work. Her visit has undoubtedly enriched our research endeavors and strengthened our commitment to excellence.
5 – 8 September 2023
Unforgettable Experience at the 8th World Congress on Oxidative Stress, Calcium Signaling, and TRP Channels! Dr. Emrah Eroğlu recently returned from an enriching journey at the 8th World Congress on Oxidative Stress, Calcium Signaling, and TRP Channels, where he had the privilege of engaging with outstanding scientists. During the event, Dr. Eroğlu served as a chair and participated in an awards committee, contributing to the academic discourse.
A special thank you to Prof. Dr. Mustafa Naziroglu for organizing this fantastic congress, providing a platform for intellectual exchange and collaboration. Dr. Eroğlu had the opportunity to connect with remarkable individuals from around the world, including Hülya Bayer (USA), Peter McNaughton (UK), Valerian Kagan (USA), Karolina Ruminska (Poland), and many more.
25 August 2023
New Paper: Dr. Emrah Eroğlu and Prof. Gürkan Öztürk’s Research Featured in iScience Journal!
We are delighted to announce that Dr. Emrah Eroğlu, as one of the corresponding authors, alongside our esteemed collaborator Prof. Gürkan Öztürk, has successfully published the paper titled “Active Shrinkage Protects Neurons Following Axonal Transection” in the prestigious iScience journal. This accomplishment underscores the impactful research contributions from our collaborative team. Congratulations to all involved! Read paper open access here.
17 August 2023
Eroglu Lab Enjoys a Refreshing Social Activity at Küçüksu Park! Taking advantage of the delightful weather, Eroglu Lab organized August’s social activity at Küçüksu Park. We kicked off the day with a multicultural breakfast, reflecting the diverse backgrounds of our lab members. The spread of international cuisines added a unique flavor to our gathering.
Following breakfast, we engaged in various games, fostering camaraderie and friendly competition among us. Laughter filled the air as we enjoyed each other’s company, creating lasting memories and strengthening our bonds as a team.
1 August 2023
Eroglu’s Lab Welcomes the Asian Chemical Biology Initiative! Eroglu’s Lab had the distinct honor of hosting the Asian Chemical Biology Initiative, welcoming esteemed guests including Professors Motonari Uesugi and Takeai Ozawa from Japan, alongside Mitsue Nakashima, the Executive Manager of ACBI. The primary goal was to strengthen collaborative efforts among Asian countries. Adding a special touch to the occasion, the visit coincided with the celebration of the 100th anniversary of diplomatic relations between Turkey and Japan, marking a historic milestone in international connections.
But that’s not all! Keep an eye out on more exciting updates as Eroglu’s Lab will particapte in ACBI program in March 2024.
27 July 2023
Thesis Defense: Design and Development of a Novel Chemogenetic Tool to Manipulate Intracellular pH Levels.
Eroglu’s Lab proudly celebrates the successful thesis defense of Asal Zaki, a valuable member of our TÜBİTAK 2232 team. Asal’s impressive journey stands as proof of her intellectual brilliance and unwavering dedication. In a symbolic gesture, we captured a moment where Asal held a shield, symbolizing her defense, while Dr. Emrah Eroğlu wielded a sword, representing the challenges overcome.
We’re thrilled to announce that Asal’s outstanding thesis project has been published in the esteemed Journal of the American Chemical Society (JACS), with her as the first author. Read paper open access here.
13 July 2023
Eroglu’s Lab Explores Çamlıca with Prof. Nikolaus Plesnila and Assist. Prof. Kıvanç Kök! We recently enjoyed a delightful visit to Çamlıca accompanied by our esteemed collaborators, further enhancing the spirit of our collaboration. From the breathtaking beauty of Çamlıca Mosque to the inspiring views from Çamlıca Hill, the day was filled with shared experiences that strengthened our connection.
Our trip concluded with a delicious traditional Turkish dinner, providing a perfect space for meaningful discussions. Such experiences go beyond the laboratory, fostering a deeper bond that transcends professional collaboration. Stay tuned for more updates as we continue to blend scientific excellence with shared moments, making every collaboration a unique journey with Eroglu’s Lab!
12 July 2023
Eroglu’s Lab is Honored to Host Global Experts for EraNet Neuron Call! Together with Professor Nikolaus Plesnila (LMU, Germany) and Professor Pierre Gressens (Diderot University, France), we’ve successfully completed our first kick-off meeting at Medipol SABITA. This marks the beginning of our collaborative journey, exploring oxidative stress in stroke under the EraNet Neuron Call grant. Utilizing advanced technologies from each partner, we’re set for groundbreaking discoveries in understanding the molecular intricacies of stroke. Excited to collaborate with this outstanding team, driven by a shared passion for unraveling the mysteries of stroke, we are dedicated to revolutionizing stroke treatment. Stay tuned for updates as we dive deeper into this critical research!
07 July 2023
Eroglu’s Lab Hosts Collaborative Session with Biolution GmbH Experts! We had the privilege of welcoming Stefan Grünert and Iris, esteemed scientists from Biolution GmbH, Vienna’s leading consultation company. With a history of trusted collaboration, their visit aimed to further enrich our partnership and explore new horizons in project development.
This meeting not only solidified our professional ties but also sparked the beginning of exciting scientific collaborations. Stefan and Iris bring a wealth of expertise, making them valuable partners in cutting-edge research. We are confident that this collaboration will be the catalyst for groundbreaking advancements in our scientific pursuits.
20 June 2023
A Memorable Seaside Escape with Eroglu’s Lab in Istanbul! We had a great day at Çubuklu Sahil, one of Istanbul’s distinctive coastal areas where history meets the sea. Following, we enjoyed a nice walk around Beykoz’s jungles. Concluding our day by exploring Hidiv Castle one of several palatial buildings along the Bosphorus, surrounded by Rose and Tulip gardens.
All thanks to our Social Activities Minister’s brilliant planning, for making it a fun time for the team. The trip refills our energy and made our lab spirit stronger. We enjoyed nature, history, and each other’s company. These activities help us work well together. Keep an eye out for more updates on our lab adventures. We’re growing and learning as a team, both in science and in friendship.
07 June 2023
Eroglu Lab’s Collaborative Journey with Prof. Hilal Lashuel! Eroğlu lab had the honor of hosting Prof. Dr. Hilal Lashuel at Medipol SABITA, our research institute. We engaged in insightful discussions and participated in the National Neuroscience Conference in Bolu. Prof. Lashuel’s groundbreaking work in protein aggregation significantly advances our understanding of neurodegenerative diseases. Excited to announce our collaboration, where we will leverage our novel mystryes tools and biosensor technologies to explore new scientific questions in this field. Looking forward to the synergies this partnership will bring and eager to witness the outcomes of our combined efforts in this vital area of study. Also, we are planing to return the visit and soon heading to Switzerland to check out his impressive institute, the Swiss Federal Institute of Technology Lausanne (EPFL).
01 June, 2023
Rebuttal to Miryam Naddaf’s Nature Commentary! We strongly disagree with concerns raised about academic freedom following the re-election of President Recep Tayyip Erdoğan. Turkey’s scientific community is vibrant, with dedicated researchers driving knowledge advancement and making significant contributions. While challenges exist, the government and institutions have made efforts to address them. Constructive dialogue and collaborative solutions are essential to strengthening academic freedom and autonomy. Turkey’s scientific community is diverse and resilient, with scientists committed to their work and advocating for positive change. Rather than focusing on potential negatives, we must foster an environment that nurtures scientific excellence, open discussions, and upholds academic freedom. Read our full opinion on LinkedIn.
24 May, 2023
Big News! Our research paper has been accepted by the prestigious Journal of the American Chemical Society! We’ve developed a groundbreaking chemogenetic approach for intracellular pH manipulation with ultra-high resolution. Huge kudos to Asal, the brilliant inventor behind this innovation! The contributions of Şeyma and Mohammed were invaluable. This achievement represents a major milestone and promises exciting possibilities in our field. Stay tuned for more updates! Read the paper open access here.
17.May.2023
New Funding! We are thrilled to announce that our consortium, consisting of researchers from Türkiye, Germany, and France with Professors Nikolaus Plesnila and Pierre Gressens, has been accepted for a prestigious European-funded project from the ERANET Neuron Call. In our VasOx project, we will be diving into the captivating world of stroke model systems. Utilizing cutting-edge chemogenetics and biosensor technologies, we aim to shed light on the role of oxidative stress. This collaborative effort promises to uncover valuable insights into stroke mechanisms.
17.May.2023
Exciting news! Our lab has just received a grant from TÜBİTAK (program code 3501). This grant will fuel our career development as we delve into the fascinating world of brain microvascular cells. We’ll be investigating the role of Nrf2 signaling and oxidative stress, aiming to uncover crucial insights into brain health and potential therapies. Big thanks to TÜBİTAK for their support! We can’t wait to make exciting progress in this field. Stay tuned for updates on our website’s news page
18 January 2023
New Fund by the European Molecular Biology Organization (EMBO)
Our lab is one of the 11 EMBO installation grant winners in 2023. The EMBO IG provides multi-year funding for principal investigators to establish and grow their groups. The grant is partially supported by the Scientific and Technological Research Council (TÜBITAK) of Türkiye. Read more here.
21-23 November, 2022
Collaboration Meeting: 1st “In Focus Meeting” (Gathering with a scientific purpose).
It was a great pleasure to host Prof. Dr. Giovanni Mann from King’s College London and Dr. Joern Steinert from Nottingham University in Istanbul Medipol University. During three days of our collaboration meeting, we listened to exciting seminars by the seniors, early career researchers had the chance to share their projects, we recorded two podcasts with our guests, and they gave a special journal club on how to read and understand a scientific paper and advised ECR for future career planning. The program was finalized by social activities such as visiting Çamlıca, Yerebatan Sarnıcı, and the Ayasofya Mosque. This goes to the gallery of our 1st In Focus Collaboration meeting.
21 October, 2022
New Research Paper: Probing Subcellular Iron Availability with Genetically Encoded Nitric Oxide Biosensors
geNOps are iron(II) dependent and genetically encoded nitric oxide biosensors. In collaborative work with Graier/Malli lab, we have unveiled that these biosensors permit probing intracellular labile ferrous iron levels in living cells. Our findings show that cell treatment with iron sucrose but not ferric carboxymaltose (two established drugs to treat iron deficiency in patients) functionalized the probe indicating cellular iron absorption. Our findings show that the geNOps approach detects available iron (II) in cultured cells and can be applied to assay functional iron (II) at the (sub)cellular level. Read here more about our novel findings.
14 October, 2022
Invited Talk: Third BenBedPhar Scientific Meeting in Bucharest
One of our research themes is investigating the role of endogenous antioxidant pathways, particularly the role of Nrf2 regulation in vascular cells. Büşra Nur Ouf, our previous master’s student, unveiled critical new insights into the relationship between hydrogen peroxide and Nrf2 activation. We cordially thank Prof. Antonio Cuadrado (President of the COST Action CA20121 BenBedPhar) and Prof. Gina Manda for inviting us to this great meeting to present our latest data.
24 August, 2022
International Award: Leopold Flohe Redox Pioneer Award
The Leopold Flohé Redox Pioneer Young Investigator Award given by the Society for Free Radical Research – Europe. The award is granted to a scientist younger than 45 years with outstanding novel findings in the field of biological redox processes, working already independently, and leading an own group of young scientists having published high quality papers. Read more about the pioneer Prof. Dr. Leopold Flohe in this article.
01 August, 2022
We have moved our lab to Medipol University.
Exactly three years ago we established our imaging laboratory at the Faculty of Engineering and Natural Sciences at Sabanci University, one of the most prestigious University in Turkiye. Now its time to move on and join forces with groups of similar interests and strong infrastructure. We are moving our lab to SABITA (Research Institute for Health Sciences and Technologies) at Istanbul Medipol University. SABITA is a comprehensive research environment that hosts multiple centers and facilities that encompass a wide spectrum of scientific, technical and applied topics from regenerative medicine to neuroscience and drug development to cancer research. A powerful infrastructure with high end imaging devices and animal model systems will allow us elevate our research to the next level insa Allah.
22 July, 2022
Thesis Defense: Investigating the role of ultra local hydrogen peroxide signals on Nrf2 signaling using genetically encoded biosensors and chemogenetic tools
Busra Nur Ouf, one of our first TÜBİTAK 2232 funded MSc students investigated the last two years the role of subcellular hydrogen peroxide and how this stable oxidant activates Nrf2 signaling pathways in cultured cells upon chemogenetic redox perturbation. We cordially congratulate Busra for her great contribution to science and wish her all the for her future endeavors.
07 July, 2022
New Results on bioRxiv: Neurons protect themselves by active shrinkage upon axonal transection
In collaboration with our partner lab headed by Prof. Dr. Gurkan Ozturk from the Medipol Universtity in Istanbul we provide exciting new mechanistic insights how neurons protect themselves. The study shows that neurons respond to axotomy by shrinking under the influence of actomyosin contraction and calpain activity, which forces water out of the cell through AQP channels. The figure on the right shows the putative pathways that are activated upon trauma. Check out the preprint here
20 June, 2022
Gülşah and Hamza on an international meeting in Italy
Our PhD students attended the “The Future of Redox Biology” meeting in Siena, which aimed to inspire the new and young generation of scientists in the field of Redox Biology Hamza and Gülşah were invited to presented some new perspectives and their ideas about chemogenetic tools and NO bio imaging in a 10 in short talk. We thank the organizers for this great meeting and unique opportunity for our young scientists allowing them to advance scientific interactions in Redox Biology. More here.
16 June, 2022
Special Issue Released
We are pleased to announce that our Special Issue Targeting genetic biosensors to intracellular signaling pathways is complete and has now been published. The special issue is available for 50 days for free using the link next to the title. We cordially thank all contributing authors for their great contributions. Enjoy reading. Read here “The preamble to the Free Radical Biology and Medicine Virtual Special Issue on Targeting genetic biosensors to intracellular signaling pathways.
12 June, 2022
Talk at International Conference
Together with our PhD students Hamza Yusuf Altun, Melike Seçilmiş and Asal Ghaffari Zaki we joined the 8th International Molecular Biology Kongress in Istanbul kindly hosted by Acıbadem University. We presented recent discoveries in redox biology with the aid of genetically encoded biosensors and chemogenetic tools and in endothelial cell signaling. The PhD students presented their newest studies and results in the poster presentations sessions. Overall, a great program, we cordially thank the MBD association for their kind invitation
5 May, 2022
New Research Paper by Gülşhah Sevimli
Gülşah’s diploma thesis which initially aimed to optimize the iron(II) dependency turned into an exciting story in collaboration with national and international researchers. Togehter with our great collaborators including Gürkan Öztürk from Medipol University and Giovanni Mann from King’s College London and their teams we established a so far unrecognized role of pericellular ferrous iron levels in cultured cells in dependence of extracellular oxygen levels. Our paper has been published in the prestigious journal Redox Biology (IF: 11.8). Check out here.
21 April, 2022
New grant: for Dr. Tuba Akgül Çağlar
Our newest lab member Dr. Tuba Akgül Çağlar, a postdoctoral researcher received from TÜBİTAK the 2218 postdoc grant for 24 month. Dr. Akgül Çağlar aims to investigate the role of nitric oxide and pain sensitive sensory neurons using genetically encoded biosensors exploiting multispectral in vivo imaging techniques. We cordially congratulate Tuba hanım for her achievement!
23 February, 2022
New preprint : by Gulsah Sevimli et al.
Title: Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels
Abstract: Iron is an essential metal for cellular metabolism and signaling, but it has adverse effects in excess. The physiological consequences of iron deficiency are well established, yet the relationship between iron supplementation and pericellular oxygen levels in cultured cells and their downstream effects on metalloproteins has been less explored. … further reading
24 Januar, 2022
New review paper : by Asal Ghaffari Zaki et al.
Title: Chemogenetic approaches to dissect the role of H2O2 in redox-dependent pathways using genetically encoded biosensors
Abstract: Chemogenetic tools are recombinant enzymes that can be targeted to specific organelles and tissues. The provision or removal of the enzyme substrate permits control of its biochemical activities. Yeast-derived enzyme D-amino acid oxidase (DAAO) represents the first of its kind for a substrate-based chemogenetic approach to modulate H2O2 concentrations within cells. Combining these powerful enzymes with multiparametric imaging methods exploiting genetically encoded biosensors has opened new lines of investigations in life sciences. In recent years, the chemogenetic DAAO…further reading
11 Januar, 2022
Thesis Defense: How much iron is good. Revisiting the role of ferrous iron supplementation in cultured cells using genetically encoded biosensors
Gülşah Sevimli, one of our first TÜBİTAK 2232 funded MSc students contributed significantly to refine the geNOps technology in our lab and graduated after two years of hard work. We cordially congratulate Gülşah for her great contriubution and interesting findings she made in cultured cells. Her thesis turned into a valuable manuscript, which will be published soon. Besides, Gülşah contributed to other papers published in high-ranking journals and we look forward to see her first-author paper to be published soon. Importantly, we are happy that Gülşah decided to continue her PhD studies in our lab, so WELCOME back Gülşah. We all look forward to work with you the next few years.
24 December, 2021
New Review Paper: by Steinhorn, Eroglu, Michel published in ARPT
Abstract: Chemogenetics refers to experimental systems that dynamically regulate the activity of a recombinant protein by providing or withholding the protein’s specific biochemical stimulus. Chemogenetic tools permit precise dynamic control of specific signaling molecules to delineate the roles of those molecules in physiology and disease. Yeast d-amino acid oxidase (DAAO) enables chemogenetic manipulation of intracellular redox balance by generating hydrogen peroxide only in the presence of d-amino acids. Advances in biosensors have allowed the precise quantitation of these signaling molecules. The combination of chemogenetic approaches with biosensor… furhter reading click here
20 October, 2021
New Research Paper: by Yusuf Ceyhun Erdoğan published in FRBM
refers to experimental systems that dynamically regulate the activity of a recombinant protein by providing or withholding the protein’s specific biochemical stimulus. Chemogenetic tools permit precise dynamic control of specific signaling molecules to delineate the roles of those molecules in physiology and disease. Yeast d-amino acid oxidase (DAAO) enables chemogenetic manipulation of intracellular redox balance by generating hydrogen peroxide only in the presence of d-amino acids. In this study, we describe and characterize in detail the features of a new modified variant of a D-amino acid oxidase termed mDAAO with improved catalytic activities For more information click here
14 September, 2021
New Research Paper: by Melike Seçilmiş published in Biosensors
In this study we advanced a single-color multiparametric imaging method, which allows simultaneous detection of hydrogen peroxide (H2O2) in multiple cell locales (nucleus, cytosol, mitochondria) using the H2O2 biosensor HyPer7. Co-culturing of endothelial cells stably expressing differentially targeted HyPer7 biosensors paved the way for co-imaging compartmentalized H2O2 signals simultaneously in neighboring cells in a single experimental setup. We termed this approach COMPARE IT, which is an acronym for co-culture-based multiparametric imaging technique. Employing this approach, we detected lower H2O2 levels in mitochondria of endothelial cells compared to the cell nucleus and cytosol under basal conditions. For more information click here!
6 August, 2021
Thesis Defense: Characterization and fine-tuning of chemogenetic tools for high-resolution multiaparametric live-cell imaging using genetically encoded biosensors.
One of our first MSc students Yusuf Ceyhun Erdoğan who contributed significantly to establish our lab graduated after two years of hard work. We warmly congratulate Ceyhun for this great work he conducted in our lab, for which he won a young investigator award from the SFRR-I. Also, Ceyhun’s work was submitted to a high-ranking journal that we expect to publish soon. Moreover, Ceyhun continues his studies in our partner lab of Roland Malli in Graz, working on a collaborative project. We wish Ceyhun all the best in his future endeavors.
23 March, 2021
Young Investigator Award: Award goes to Yusuf Ceyhun Erdoğan
We cordially congratulate our Masters student Yusuf Ceyhun Erdoğan for his great achievement in the field of Free Radical Research. Ceyhun was awarded the Young Investigator Award at the 20th Biennial Meeting (this year online) of the Society for Free Radical Research International. Ceyhun presented his thesis work, which deals with the characterization and application and fine-tuning of chemogenetic tools in cultured cells. Well done Ceyhun! Read more here.
11 December, 2020
Online Conference: Boğaziçi Biotech Conference on the 15th – 17th January 2021
Students and young investigators! You are cordially invited to join an exciting online conference and workshop organized by the Boğaziçi Üniversitesi Bilim Kulübü Biyoloji Kurulu. International leading scientists will give informative talks to interested biotech students. Looking forward to welcoming you on the 15th of January. For more information visit bounbiotech.com
20 September, 2020
Thesis Defense: Shedding New Light On Intracellular Signaling Pathways – Establishing High Resolution Live-Cell Imaging Techniques Using Genetically Encoded Biosensors.
Hamza Yusuf Altun, our SU student in the Bio program at FENS successfully defended his thesis and well earned his MSc degree. CONGRATULATIONS Hamza, you did it meeen! Besides establishing real-time high-resolution imaging with various biosensors, Hamza also established new approaches in multichromatic and FRET imaging techniques and developed new ideas in how to exploit recombinant biosensors. We look forward to welcome again Hamza in October as a PhD student in our lab.
8 July, 2020
Thesis Defense: Real-Time Imaging of Nitric Oxide (NO) Signals Derived From Differentially Targeted Endothelial Nitric Oxide Synthase (eNOS) Using Genetically Encoded Biosensors
Emir Mete Özgürses, a visiting student from Biruni University successfully defended his MSc thesis. CONGRATULATIONS! His responses to the examination committee demonstrated his depth of knowledge in the application and interpretation of genetically encoded biosensors for nitric oxide and calcium. Congrats, Emir, and all the best in your future endeavors.
20 June, 2020
New Research Article: Differential endothelial signaling responses elicited by chemogenetic H2O2 synthesis
Hydrogen peroxide (H2O2) modulates critical phosphorylation pathways in vascular endothelial cells, many of which affect endothelial nitric oxide synthase (eNOS) signal transduction. Both intracellular and extracellular sources of H2O2 have been implicated in eNOS regulation, yet the specific endothelial pathways remain incompletely understood. Here we exploited chemogenetic approaches and live-cell imaging methods to both generate and detect H2O2 in different subcellular compartments (cytosol, nucleus, and caveolae) of cultured EA.hy926 human endothelial cells. Read more
23 May, 2020
News & Views: YES (again) to local NO
Check our News & Views article just published in Nature Chemical Biology. In this article we criticallly assess a new NO imaging technology based on targeted DNA dublex scaffolds. The authors used these novel probes to visualize local NO formation in the Golgi apparatus and plasma membrane in cancer cells. Read more
15 April, 2020
Young Investigator Award: The Turkish Science Academy awarded us the Bilim Akademisi Genç Bilim insanları Ödül Programı (BAGEP)
The Turkish Academy of Sciences rewards each year about 40 young scientists nominated across different disciplines with the BAGEP award. The BAGEP award program was launched in 2013 to identify, reward and support the best young academics and researchers. Read more.
15 March, 2020
New Research Paper Released: Ultrasensitive Genetically Encoded Indicator for Hydrogen Peroxide Identifies Roles for the Oxidant in Cell Migration and Mitochondrial Function
Hydrogen peroxide (H2O2) is a key redox intermediate generated within cells. Existing probes for H2O2 have not solved the problem of detection of the ultra-low concentrations of the oxidant: these reporters are not sensitive enough, or pH-dependent, or insufficiently bright, or not functional in mammalian cells, or have poor dynamic range. Here we present HyPer7, the first bright, pH-stable, ultrafast, and ultrasensitive ratiometric H2O2 probe. HyPer7 is fully functional in mammalian cells and in other higher eukaryotes. Read more…
06 December, 2019
Collaboration Meeting Prof. Roland Malli: Our old teacher, friend and collaboration partner Roland Malli who is the head of a world leading bio-imaging lab at the Medical University of Graz and CEO of Next Generation Fluorescence Imaging (www.ngfi.eu) visited our University and our group members for two days in Istanbul. We cordially thank RM for those exciting meetings, discussions and collaboration plans.
26 November, 2019
Celebrating Teachers Day: The 24th of November is Teachers Day in Turkey, which has a long history here. My dear group members brought cake and börek to our weekly Jounal Club and we celebrated the Teachers day together. Special thanks to SS, YCE, MEO, HYA, ZC, ZK, SF, and NC.
17 September, 2019
New Research Paper Released: Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods
The direct detection of the low physiological concentrations of NO that are present in endothelial cells represents a significant analytical challenge. In these studies, we have used the powerful geNOps biosensors to measure NO and other key signaling molecules in living endothelial cells in real time using fluorescence microscopy. These approaches have provided insights into the mechanisms whereby NO synthesis is regulated and call into question many prior conclusions about the intracellular pathways that regulate eNOS. Read more…
06 August, 2019
New Grant: TUBITAK 2232 International Fellowship for Outstanding Researchers
The Scientific and Technological Research Council of Turkey (TUBITAK) granted us the 2232 International Fellowship for Outstanding Researchers. Interested PhD candidates (3 positions available) are welcome to apply for a fully funded Bio program. For more details review our ‘Research‘ page or ‘Contact‘ us directly. Read more…
